2-Bromo-4-ethylpyridine is a significant chemical compound widely recognized for its utility in various scientific and industrial applications. It serves as a foundational intermediate, particularly in the synthesis of complex organic molecules. This detailed overview delves into its chemical properties, applications, and market availability, providing a holistic understanding of its importance.

1. Versatile Building Block: This compound is essential for synthesizing substituted pyridine derivatives used across pharmaceutical, agrochemical, and material science sectors.
2. Critical Properties: Known for its distinct molecular formula (C₇H₈BrN), molecular weight (186.05 g/mol), and a CAS number (54453-91-7), it typically appears as a yellow or colorless liquid.
3. Market Dynamics: While widely available from various suppliers like Genprice and Chem-Impex, some major vendors, such as Sigma-Aldrich, have discontinued its supply, highlighting the importance of alternative sources.

2-Bromo-4-ethylpyridine is an organic compound characterized by a pyridine ring substituted with a bromine atom at the 2-position and an ethyl group at the 4-position. This specific arrangement gives it unique reactivity, making it invaluable in synthetic chemistry.

The structural representation of 2-Bromo-4-ethylpyridine, highlighting its bromine and ethyl group positions on the pyridine ring.

Understanding the basic chemical properties is crucial for handling and utilizing 2-Bromo-4-ethylpyridine effectively. Its molecular structure dictates its physical state, solubility, and reactivity.

Molecular and CAS Information

1. CAS Number: 54453-91-7
2. Molecular Formula: C₇H₈BrN
3. Molecular Weight: 186.05 g/mol
4. IUPAC-like Name: 2-Bromo-4-ethylpyridine (also known as 4-ethyl-2-bromopyridine)

Physical and Chemical Properties

This compound generally presents as a liquid with specific physical attributes that guide its application and storage protocols. These properties are critical for laboratory and industrial safety, as well as for ensuring product stability and purity.

Table summarising key physical and chemical characteristics of 2-Bromo-4-ethylpyridine.

The versatility of 2-Bromo-4-ethylpyridine stems from its unique chemical reactivity, particularly the bromine atom which can be easily displaced in various reactions. This makes it an indispensable component in synthesizing more complex molecules for diverse fields.

Synthetic Chemistry and Intermediate Production

In organic synthesis, 2-Bromo-4-ethylpyridine acts as a pivotal building block. Its pyridine core and reactive bromine allow for various transformations, including cross-coupling reactions (such as Suzuki or Heck couplings), nucleophilic substitution, and other functionalizations.

Pharmaceutical and Agrochemical Industries

This compound plays a crucial role in developing Active Pharmaceutical Ingredients (APIs) and agrochemical products. Its ability to form substituted pyridine derivatives makes it valuable for creating new drugs and crop protection agents.

1. Pharmaceuticals: Used in medicinal chemistry for synthesizing complex molecules, including potential kinase inhibitors and other therapeutic agents.
2. Agrochemicals: Essential for the production of herbicides, insecticides, and fungicides, contributing to advanced crop protection solutions.

Material Science and Proteomics

Beyond pharmaceuticals and agrochemicals, 2-Bromo-4-ethylpyridine finds utility in material science for creating novel functional materials and in advanced proteomics research for labeling or modifying biomolecules.

2-Bromo-4-ethylpyridine is a widely traded laboratory reagent. However, its availability can vary between suppliers, with some major distributors discontinuing the product, necessitating a broad search for reliable sources.

Supplier Overview and Product Offerings

Genprice is a high-quality laboratory reagent, typically available in 1-gram quantities with a purity often ≥96%.