TNF alpha huma RECOMBINANT
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Product Details: Tumor Necrosis Factor (TNF alpha) human (RECOMBINANT)

Basic Information

 
Product ID: GF-090-4
Product Name: Tumor Necrosis Factor (TNF alpha) human (RECOMBINANT)
Unit: 50µg
Price: 665 Euro
Availability: Available
Category: Growth Factors, Cytokines, Receptors and their Antibodies
Subcategory: Growth Factors/Cytokines/Enzymes

 

Product Details

 
Description: Human Tumor necrosis factor (TNF- alpha), also known as Cachectin, is a cytokine composed of 157 amino acid residues, having a molecular weight of 17 kDa (monomer). There is 79% homology between human and murine TNF- alpha, including conserved cysteine residues which form an intrachain disulfide bridge. Biological effects of this cytokine include antitumor activity in vivo and in vitro, activation of polymorphonuclear leukocytes, antiviral activity, and the induction of the release if Interleukin-1 or colony stimulating factors from a variety of sources.

Human TNF- alpha (Cachectin) is produced in genetically engineered yeast, and purified by sequential chromatography.

 
Molecular Weight: 17 KDa
Biological Activity: The cell cytolytic activity is determined in the L929 cells (3 x 104 cells/assay) and it is 2-4 x 108 U/mg.

 
Formulation: At concentration of 1 mg/ml in 0.02M Tris-HCl/ 0.15 M NaCl (pH 8.0)
Purity: Over 95% pure by SDS gel electrophoresis.
Storage Conditions: Store at -80°C.
Stability: At least 1 year at -80°C.
Temperature: -80°C
References: 1. Feinstein, R., Kanety, H., Papa, M.Z., lunenfeld, B., and Karasik, A., (1993) The Journal of Biological Chemistry, Vol 268, No. 35, December, 2. 6055-26058
2. Kalthoff, H., Roeder, C., Brockhaus, M., Thiele, H.G., and Schmiegel, W., (1993) The Journal of Biological Chemistry, Vol 268, No. 4, February, 2762-2766 3. Chaturvedi, M.M. et al. (1994). J. Biol Chem. 269, 14575-14583.