Anti-Jnk Inhibitor Protein 1 (JIP1)

Monoclonal

Reactivity: Human

References:  

Yasuda et al. (1999) The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 19:7245-54. 

            Whitmarsh et al. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation.  Genes Dev. 15:2421-32. 

Kelkar et al. (2003) Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).  Proc Natl Acad Sci U S A. 19;100(17):9843-8.

Inventor: Roger Davis, Ph.D.

Docket: UMMC 06-52

Anti-Jnk Inhibitor Protein 2 (JIP2)

Monoclonal

Reactivity: Human

References:  

Yasuda et al. (1999) The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 19:7245-54. 

            Whitmarsh et al. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation.  Genes Dev. 15:2421-32. 

Kelkar et al. (2003) Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).  Proc Natl Acad Sci U S A. 19;100(17):9843-8.

Inventor: Roger Davis, Ph.D.

Docket: UMMC 06-53

Anti-Zinc finger protein (ZPR1)

Monoclonal

Reactivity: human, mouse

References:

Gangwani et al. (2001) Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein. Nature Cell Bio 3: 376-383.

Gangwani et al. (2005) ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to cajal bodies. Mol and Cell Bio 25: 2744-2756.

Inventor: Roger Davis, Ph.D.

Anti-Toll-like receptor 2 (TLR2)

Monoclonal

Reactivity: human

Reference:

Sandor et al. (2003) Importance of extra- and intracellular domains of TLR1 and TLR2 in NFқB signaling. Journal of Cell Biology 162: 1099-1110.

Inventor: Evelyn Kurt-Jones

Anti-Norwalk Virus (1C9 and 1D8)

Monoclonal

References:  

Herrmann et al. (1995) Monoclonal antibodies for detection of Norwalk virus antigen in stools. J Clin Microbio 33:2511-2513.  

Additional Information: Antibodies against 8FIIa strain of Norwalk Virus, no cross reactivity with other caliciviruses, 1D8 antibody reacts to the N terminus of the viral capsid.

Inventor: John Hermann, Ph.D.

Docket: UMMC 95-22

Anti-Astrovirus (8E7)

Monoclonal

Inventor: John Hermann, Ph.D.

References:  

Herrmann et al. (1990) Diagnosis of astrovirus gastroenteritis by antigen detection with monoclonal antibodies. J Infect Dis 2:226-9. 

Additional Information: Reacts with all known types of astroviruses which cause gastroenteritis, no cross reactivity with other caliciviruses, antibody isotype IgG1

Docket: UMMC 89-02

Rotavirus (3F7)

Monoclonal

Reference:

Cukor et al. (1984) Detection of Rotavirus in human stools by using monoclonal antibody. Journal of Clinical Microbiology  888-893.

Additional Information: ATTC# SD4052, no cross reactivity with other caliciviruses.

Docket: UMMC 84-02.

Inventor: John Hermann, Ph.D.

Anti-Newcastle disease virus hemagglutinin neuraminidase (HN4a)

Monoclonal

References:

Iorio et al. (1983) Monoclonal antibodies to Newcastle disease virus: delineation of four epitopes on the HN glycoprotein. J Virology  48: 440-450.

Iorio et al. (1984) Neutralization of Newcastle disease virus by monoclonal antibodies to the hemagglutinin-neuraminidase glycoprotein: requirement for antibodies to four sites for complete neutralization. J Virology 51:445-451.

Additional information:  Australia-Victoria virus strain

Inventor: Ronald Iorio, Ph.D., Professor Molecular Genetics & Microbiology

Docket: UMMC 02-21

Anti-Newcastle disease virus hemagglutinin neuraminidase (HN14f)

Monoclonal

Reference: Available upon request

Additional information: Australia-Victoria virus strain, antibody recognizes a linear epitope in the protein

Inventor: Ronald Iorio, Ph.D., Professor Molecular Genetics & Microbiology

Docket: UMMC 01-38

Anti-Newcastle disease virus fusion protein (IC114)

Monoclonal

Reference: Available upon request

Additional information:  Australia-Victoria virus strain

Inventor: Ronald Iorio, Ph.D., Professor Molecular Genetics & Microbiology

Docket: UMMC 01-35

Anti-Ubiquitin Activating E1 Enzyme

Monoclonal

Reference: Available upon request

Inventor: Kenneth Rock, MD, Chair of Pathology

Docket: UMMC00-32

Polyclonal Antibodies:

Anti-mitofilin (specific to mitochondria) 

Rabbit polyclonal

Reactivity: Human, mouse, rat, cat, dog

Reference: Odgren et al. (1996) Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains. J Cell Science 109:2253-2264.

Additional information: This antibody detects all known mitofilin isoforms in western blots and intensely labels mitochondria in immunofluorescense and immuno-electron microscopy.  Docket: UMMC05-63  

Anti-tub 1 (regulator of fat storage and life span)

Rabbit polyclonal

Reactivity: C. elegans

Reference: Mukhopadhyay et al. (2005) C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metabolism 2:35-42.

Inventor: Heidi Tissenbaum Ph.D.

Docket: UMMC05-11

Anti-SIR2.1 (silent information regulator 2, family of NAD+-dependent protein deacetylases)

Rabbit polyclonal

Reactivity: C. elegans

Additional Information: Polyclonal antibodies available for both the full-length and N' truncated his tagged SIR2.1

Inventor: Heidi Tissenbaum Ph.D.

Docket: UMMC05-10

Anti-DAF-16 (forkhead transcription factor)

Rabbit polyclonal

Reactivity: C. elegans

Reference: Wook Oh et al. (2005) Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nature Genetics

Inventor: Heidi Tissenbaum Ph.D.

Docket: UMMC05-09

Anti-DAF-3(forkhead transcription factor)

Rabbit polyclonal

Reactivity: C. elegans

Reference: manuscript accepted in Cell

Inventor: Marian Walhout, Ph.D., Program Gene Function & Expression

Docket: UMMC05-09

Anti-JNK-1 (c-Jun N-terminal kinase)

Rabbit polyclonal

Reactivity: C. elegans

Reference: Wook Oh et al. (2005) JNK regulates lifespan in C. elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.  PNAS 102: 4494-4499.

Inventor: Heidi Tissenbaum Ph.D.

Docket:  UMMC05-08

Anti-HMGN1 (high mobility group protein 14)

Rabbit polyclonal

Reactivity: Human

Reference: Hill et al. (2005) Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling. J of Biological Chemistry 280: 41777-41783.

Docket: UMMC05-03

Anti-DNA-binding protein B (dbpB)

Rabbit polyclonal

Reactivity: Human

Reference: Leonard et al. (1998) Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. J of Biological Chemistry 273: 5443-5446.

Additional information: Antibody against C-terminal 15 amino acids or entire His-tagged dbpB protein

Inventor: Jack Leonard, Ph.D.

Anti-Selenodeiodinase type I (SeD1)

Rabbit polyclonal

Reactivity: rat

Reference: Leonard et al. (1999) The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat. Endocrinology  140: 2206-2215.

Additional information: Antibody against C-terminus

Inventor: Jack Leonard, Ph.D.

Anti-p27 (27 kDa substrate binding subunit of type I deiodinase)

Rabbit polyclonal

Reactivity: rat

References:

Leonard et al. (2001) Characterization of the subunit structure of the catalytically active type I iodothyronine. J of Biological Chemistry 276: 2600-2607.

Leonard et al. (2005) Characterization of the protein dimerization domain responsible for assembly of functional selenodeiodinases. J of Biological Chemistry 280: 11093-1110.

Additional information: Antibody against 21 C-terminal amino acids 

Inventor: Jack Leonard, Ph.D.

Anti-Selenodeiodinase type II (SeD2)

Rabbit polyclonal

Reactivity: rat

References:

Leonard et al. (1999) The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat. Endocrinology  140: 2206-2215.

Leonard et al. (2003) Hypothalamic type II iodothyronine deiodinase: a light and electronmicroscopic study. Brain Research 976: 130-134.

Leonard et al. (2005) Characterization of the protein dimerization domain responsible for assembly of functional selenodeiodinases. J of Biological Chemistry 280: 11093-1110.

Additional information: Antibody against C-terminus or catalytic core of SeD2

Inventor: Jack Leonard, Ph.D.

Anti-p29 (29 kDa substrate binding subunit of type II deiodinase)

Rabbit polyclonal

Reactivity: rat

Reference: Leonard et al. (2000) Cloning, expression, and functional characterization of the substrate binding subunit of type II iodothyronine 5’-deiodinase. J of Biological Chemistry 275: 25194-25201.

Additional information: Antibody against C-terminus

Inventor: Jack Leonard, Ph.D.

Anti-Selenodeiodinase type III (SeD3)

Rabbit polyclonal

Reactivity: chicken

Reference: Leonard et al. (2002) Specific detection of type III iodothyronine deiodinase protein in chicken cerebellar purkinje cells. Endocrinology  143: 2700-2707.

Inventor: Jack Leonard, Ph.D.

Anti-Myosin Va

Rabbit polyclonal

Reactivity: rat

Reference:

Leonard et al. (2000) Myosin V plays an essential role in the thyroid hormone-dependent endocytosis of type II iodothyronine 5’-deiodinase. J of Biological Chemistry  275: 31701-31707.

                Leonard et al. (2001) Real-time visualization of processive myosin 5a-mediated vesicle movement in living astrocytes. J of Biological Chemistry 276: 35652-35659

Additional information: Antibody against C-terminus or coiled-coiled domain

Inventor: Jack Leonard, Ph.D.

Docket: UMMC 05-44

Anti-Protein Disulfide Isomerase (PDI)

Rabbit polyclonal

Reactivity: rat

Reference: Leonard et al. (1991) Characterization of a n-bromoacetyl-l-thyroxine affinity- labeled 55-kD protein as protein disulfide isomerase in cultured glial cells. Endocrinology 129: 2011-2016.

Inventor: Jack Leonard, Ph.D., Professor Physiology

Anti-α-nucleolin

Rabbit polyclonal

Reactivity: rat

Inventor: Jack Leonard, Ph.D.

Anti-EBP-50 (ezrin-binding phosphoprotein)

Rabbit polyclonal

Reactivity: human, rat, mouse

Reference: Lambert et al. (2003) Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of ranvier. J of Cell Biology 162: 489-498.

Inventor: Stephen Lambert, Ph.D.

Docket: UMMC 03-28

Anti-supervillin/archvillin

Rabbit polyclonal

Reactivity: human, mouse, bovine, hamster

References:

Luna et al. (2002) Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J of Bio Chem 277: 43399-43409.

Luna et al. (2003) Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. J Cell Science 116: 2261-2275.

                Luna et al. (2004) Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle. J Cell Science  117:5043-5057.

Additional information: amino acids 1-340, hybridomas available upon request

Inventor: Beth Luna, Ph.D.

Docket: UMMC 03-37

Anti-pepA (SVIL)

Rabbit polyclonal

Reactivity: bovine

Reference: Luna et al. (2003) Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. J of Cell Science 116: 2261-2275.

Additional information: amino acids 900-918

Inventor: Beth Luna, Ph.D.

Anti-phospho-specific IRE1α

Rabbit polyclonal

Reactivity: human, rat, mouse

Reference: Available upon request

Inventor: Fumihiko Urano, MD, Ph.D.

Docket: UMMC 05-18

Anti-total -specific IRE1α

Rabbit polyclonal

Reactivity: human, rat, mouse

Reference: Available upon request

Inventor: Fumihiko Urano, MD, Ph.D.

Docket: UMMC 06-56

Anti-WFS1 (Wolfram syndrome 1 gene product)

Rabbit polyclonal

Reactivity: human, rat

Reference: Takeda et al. (2001) WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. Human Molecular Genetics  10: 477-484.

Additional information: Antibody against C-terminus

Inventor: Fumihiko Urano, MD, Ph.D.

Docket: UMMC 06-54