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Glucose Transporter (Gluts1-13) Antibodies
   

 

 Items

 Antigen
peptide
location

 Ab
Host

Antiserum
Cat # (100 ul)

Aff. Pure IgG
or Mab
Cat # (100 ug)

* Control Peptide
Cat# (100 ug)

Glut-1
(Ab #1)

 M, 12 aa,
Cytoplasmic

Rb, poly

GT11-S

GT11-A

 GT11-P

Glut-1
(Ab #2)

 H, 13 aa,
Cytoplasmic

Rb, poly

GT12-S

GT12-A

GT12-P

Glut-1
(Ab #3)

H, 15 aa,
Cytoplasmic

Rb, poly 

GT13-S

GT13-A

 GT13-P

Glut 1
(Ab #4)

 H, 15aa, ~NT,
Extracelluar

Rb, poly

 *

GT14-A

GT14-P

 

Glut 1
(Ab #5)

 

 H Glut-1
protein (EC)

 

m,
mono

 

 *

 

GT15-M

 

 *

Glut-2
(Ab #1)

R, 16 aa, ~I

Rb, poly

GT21-S

GT21-A

GT21-P

Glut-2
(Ab #2)

H, 14 aa,
Cytoplasmic

Rb, poly

GT22-S

GT22-A

GT22-P

 

Glut-2
(Ab #3)

 

h glut2
protein (EC)

 

m,
mono

 

 

GT23-M

 

 

Glut-2
(Ab #4)

 

m, glut2
protein (EC)

 

m,
mono

 

 

GT24-M

 

Glut-3
(Ab #1)

M, 12 aa,
Cytoplasmic

Rb, poly

GT31-S

GT31-A

 GT31-P

Glut-3
(Ab #2)

H, 12 aa,
Cytoplasmic

Rb, poly

GT32-S

GT32-A

GT32-P

Glut-3
(Ab #3)

 H, 13aa, ~NT,
Extracellular

 Rb, poly

 *

GT33-A

GT33-P

 

Glut-3
(Ab #4)

 

h glut3
protein (EC)

 

m,
mono

 

 

GT34-M

 

Glut-4
(Ab #1)

M, 12 aa,
Cytoplasmic

Rb, poly

GT41-S

GT41-A

GT41-P

Glut-4
(Ab #2)

H, 13aa, ~NT,
Extracellular

Rb, poly

 *

 GT42-A

 GT42-P

 

Glut-4
(Ab #3)

 

rat glut-4
protein (CP)

m, mono

 

 

GT43-M

 

Glut-5
(Ab #1)

R, 13 aa,
Cytoplasmic

Rb, poly

GT51-S

GT51-A

GT51-P

Glut-5
(Ab #2)

H, 12 aa,
Cytoplasmic

Rb, poly

GT52-S

GT52-A

GT52-P

 

Glut-5
(Ab #3)

 

human glut5
protein (EC)

 

m, mono

 

 

GT53-M

 

Glut-6

H, 16 a,
Cytoplasmic

Rb, poly

GT62-S

 GT62-A

GT62-P

Glut-7
(Ab #1)

R, 14 aa,
Cytoplasmic

 Rb, poly

GT71-S

GT71-A

GT71-A

Glut-7
(Ab #2)

R, 12 aa,
Cytoplasmic

 Rb, poly

GT72-S

GT72-A

GT72-P

Glut-7
(Ab #2)

H, 12 aa,
Cytoplasmic

 Rb, poly

GT73-S

GT73-A

GT73-P

Glut-8

M, 11 aa,
Cytoplasmic

 Rb, poly

 GT81-S

GT81-A

GT81-P

Glut-9

H, 21 aa ,
Cytoplasmic

Rb, poly

GT91-S

GT91-A

GT91-P

Glut-10

H, 16 aa,
Cytoplasmic

Rb, poly

GT101-S

 GT101-A

GT101-P

Glut-11

H, 16 aa,
Cytoplasmic

Rb, poly

GT111-S

 GT111-S

GT111-S

 

Glut-12

 

H, 18 aa,
Cytoplasmic

 

Rb, poly

 

GT122-S

 

GT122-A

 

GT122-P

 

Glut-13

 

h, 16 aa,
Cytoplasmic

 

Rb, poly

 

GT132-S

 

GT132-A

 

GT132-P



M= Mouse; R=Rat; H=Human; Rb=Rabbit; G=goat; B=Bovine, MO=Monkey; P=pig; CT= near C-terminus; NT=near N-terminus; Internal=Middle of protein. EC=extracellular; CP=cytoplasmic domains *


Glucose Transporter (Gluts1-13) Antibodies-General Information

 

Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters (Glut or SLC2A family). Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 9 proteins (Glut-1 to Glut-14, Mol. Wt. 40-60 kDa). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. There is a large extracellualr domain between TM1-TM2 and a cytoplasmic domain between TM6-TM7. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting.

Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. Glut-1 mediates glucose transport into red cells, and throughout the blood brain barrier. It is ubiquitously expressed and transport glucose in most cells. Glut-2 provides glucose to the liver and pancreatic cells. Glut-3 is the main transporter in neurons, whereas Glut-4 is primarily expressed in muscle and adipose tissue and regulated by insulin. Glut-5 transports fructose in intestine and testis. Glut-6 name was previously assigned to a pseudoegene. Now Glut-9 has been renamed as Glut-6 (human 507 aa; ~45% identity with Glut-8). It is highly expressed in brain, spleen, and leukocytes. Glut-7, expressed in liver and other gluconeogenic tissues, mediates glucose flux across endoplasmic reticulum membrane. Most recently, Glut-8 (mouse/rat/human 477 aa, ~30% identity with Glut-1) has been cloned and characterized. High levels are found in adult testis and placenta. Human Glut-9 (540 aa; chromosome 4p15.3-p16) is approx 45% identical with Glut-5, and 38% with Glut-1. It is expressed in kidney, followed by liver. Glut-9 is also detected in placenta, lung, blood leukocytes, heart, and skeletal muscle. Human Glut-10 (541 aa, chromosome 20q13.1; ~30-35% homology with Glut-3 and Glut-8) has been identified as a candidate gene for NIDDM susceptibility. It is widely expressed with highest levels in liver and pancreas. Glut-11 (496 aa, chromosome 22q11.2; ~41% identity with Glut-5) is expressed in heart and skeletal muscle. Recently, a few novel members of Glut family have been identified. Glut-12 (human 617 aa; 29% identity with Glut-4 and 40% with Glut-10). It is expressed in skeletal muscle, adipose tissue, and small intestine. Glut-13 or H+ myo-inositol transporter (HMIT, rat 618 aa; human 629 aa; ~36% identity with Glut-8). It is predominantly expressed in brain.

ADI has produced highly specific rabbit-anti Glut-1-13 using antigenic sequences unique to each protein. These antibodies do not crossreact with each other and can be used to study specific Gluts in mouse, rat, and human tissues. Availability of multiple antibodies to the same protein should help select antibodies with more interspecies crossreactivity, and to achieve better results in a given technique. The control/blocking peptides, used for immunization, are also available to determine specificity of antibodies.

Information on Antibodies to Sodium Glucose Transproters (SGLT1-4)

New Nomenclature (HUGO) of Gluts

 

Protein

Other Names ,
Major Isoform

Gene Name

Chromosome Localization

Accession Nos.

Major TissueExpression

GLUT1

GTR1, H, 492

SLC2A1

1p35-31.3

AC023331

Erythrocytes, brain

GLUT2

GTR2, H, 524 aa

SLC2A2

3q26.2-27

AC068853

Liver, islets

GLUT3

GTR3, H, 496 aa

SLC2A3

12p13.3

AC007536

Brain (neuronal)

GLUT4

GTR4, H, 509 aa

SLC2A4

17p13

AC003688

Muscle, fat, heart

GLUT5