Forckenbeckstraße 6,

D-52074 Aachen

• Simple and sensitive alkaline phosphatase tracers
• 18-month stability of the kit and key reagents
• Quick 2-hour incubation and 1-hour development
• Important assays like:
• cAMP and cGMP for cell signaling
• 8-isoprostane for oxidative injury
• TXB2 and 6-keto PGF1α for thrombosis and hematology
• PGE2, LTB4, LTC4, and cysLT for inflammation/allergy

cAMP EIA Kit 133-16475  385 Euro
Adenosine 3’,5’ cyclic monophosphate (cAMP) is a ubiquitous cellular second
messenger that is a critical component of a signal transduction pathway linking
membrane receptors and their ligands to the activation of internal cellular
enzymatic activity and gene expression. The abundance of cAMP within a given
cell serves as a marker for activation by agonists acting at cell surface.
 

cGMP EIA Kit 133-16475 385 Euro
Guanosine 3’,5’ cyclic monophosphate (cGMP) is a key intracellular second
messenger molecule which transduces cellular signaling events in response to a
variety of hormones, autacoids, and drugs. The abundance of cGMP within a
given cell serves as a marker for activation by agonists acting through particulate
guanylate cyclase at the cell surface, or intracellular activation of soluble guanylate
cyclase by nitric oxide.

Cysteinyl-Leukotriene EIA Kit 133-16462 385 Euro
The leukotrienes (LTs) LTC4, LTD4, and LTE4 are collectively referred to as
cysteinyl-leukotrienes (cysLTs). LTC4 and LTD4 are potent mediators of asthma
and hypersensitivity. They induce bronchoconstriction, increase microvascular
permeability, and are vasoconstrictors of coronary arteries. CysLTs are excreted in
urine as intact LTE4 (~9-12%) and LTE4 metabolites.

Leukotriene B4 EIA Kit 1333-16464 385 Euro
Leukotriene B4 (LTB4) is a potent mediator of inflammation synthesized from
arachidonic acid by the combined action of 5-lipoxygenase and LTA4 hydrolase. It
stimulates a number of leukocyte functions, including aggregation, stimulation of
ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production,
chemotaxis, and chemokinesis.

Leukotriene C4 EIA Kit 1333-17331 385 Euro
Leukotriene C4 (LTC4) is a potent mediator of asthma and hypersensitivity
derived via the 5-lipoxygenase pathway in leukocytes, eosinophils, mast cells,
and macrophages. It induces bronchoconstriction, increases microvascular
permeability, and vasoconstriction of coronary arteries.

Leukotriene E4 EIA Kit 1333-16547 385 Euro
Leukotriene E4 (LTE4) is a product of the 5-lipoxygenase (5-LO) pathway in
activated mast cells, eosinophils, and monocytes. LTA4, the primary 5-LO
metabolite, is converted to LTC4 and sequentially to LTD4 and LTE4 in the host
cell, or by transcellular metabolism in erythrocytes, platelets, or neutrophils. LTC4
and LTD4 are excreted in urine as intact LTE4 and LTE4 metabolites.

Prostaglandin E2 EIA Kit 1333-16359 385 Euro
Prostaglandin E2 (PGE2) is one of the primary cyclooxygenase (COX) products
of arachidonic acid metabolism and one of the most widely investigated PGs.
Its activity influences inflammation, fertility and parturition, gastric mucosal
integrity, and immune modulation. The effects of PGE2 are transduced by at least
four distinct receptors designated EP1, EP2, EP3, and EP4.

6-keto Prostaglandin F1α EIA Kit 1333-16476 385 Euro
Prostacyclin (Prostaglandin I2; PGI2) is formed from arachidonic acid primarily by
the vascular endothelium and renal cortex. It is a potent vasodilator and inhibitor
of platelet aggregation. PGI2 is non-enzymatically hydrated to 6-keto PGF1α (t1/2
= 2-3 minutes), and then quickly converted to the major metabolite, 2,3-dinor-6-
keto PGF1α (t1/2 = 30 minutes) and excreted in the urine.

Prostaglandin F2α EIA Kit 1333-17333 385 Euro
Prostaglandin F2α (PGF2α) is one of the five primary prostaglandins derived
enzymatically directly from the endoperoxide PGH2 via the cyclooxygenase
(COX) metabolic pathway. The majority of the functional roles ascribed to PGF2α
relate to fertility, pregnancy, and parturition. PGF2α is a potent luteolytic agent
and uterine stimulant, and is part of the cascade of myometrial stimulants which
induce and sustain labor.

8-iso Prostaglandin F2α EIA Kit 1333-16465 385 Euro
8-isoprostane (8-iso PGF2α) is the most studied member of the isoprostane
family of eicosanoids produced by the random oxidation of tissue phospholipids
by oxygen radicals. 8-iso PGF2α appears in the plasma and urine under normal
conditions and is elevated by oxidative injury.

Thromboxane B2 EIA Kit 1333-16463 385 Euro
Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and
causes irreversible platelet aggregation and contraction of vascular and bronchial
smooth muscle. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2,
which is then quickly metabolized (t1/2 = 5-7 minutes) to urinary metabolites for
clearance by the kidneys.

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