> Immunopore diagnostic membrane

Features and Benefits
 

• High sensitivity.
  Capture line shows high intensity, making low positives easy to read and improving test range.
• High consistency.
  Demonstrate outstanding within- and between-batch consistency for lateral wicking rates (see graphs), making test development more predictable.
• Long shelf life.
  No significant performance change after three years' storage under ambient conditions, simplifying membrane handling and storage operations.
• Product versatility.
  Strong results regardless of capture reagent or analyte type. Can be utilized in virtually all tests.

Product Range and Properties
Immunopore SP
Mylar cast membrane construction. Maximum sensitivity coupled with low flow/wicking rate. Ideal for use with low-viscosity samples when maximum capture line intensity is required.

Immunopore FP
Mylar cast membrane construction. Excellent general membrane offers high capture line intensity coupled with faster flow/wicking rate.

Immunopore RP
Mylar cast membrane construction. Fastest flowing membrane, yielding shorter test times while still retaining excellent capture line intensity and reproducibility.

Standard Sizes
Available in 50m rolls of 25mm width, for other sizes please inquire.

> Conjugate release

Features and Benefits

• Choice of product.
  Rapid Release materials are optimized to provide improved performance without blocking, while Standard Release materials allow the development of proprietary blocking protocols.
• Inherently hydrophilic conjugate pads.
  Do not require treatment prior to conjugate application, decreasing time required for diagnostic kit production.
• Innovative design.
  Enables the conjugate to dry as a solid phase without colloidal system deterioration. Open structure allows rapid pad penetration by both conjugate and sample.
• Product versatility.
  Can be used as combined sample wick/conjugate release pads when additional wicks are not desired.

Product Range and Properties

Rapid 24/Rapid 27
No additional blocking step is required, accelerating assay development and simplifying manufacturing. Typically release more conjugate than untreated pads, reducing reagent costs. Pads rewet rapidly and capture line intensity is increased, significantly improving performance. Rapid 24 has higher absorption capacity and greater flexibility, while Rapid 27 has greater tensile strength.

Standard 14/Standard 17 Untreated grades ideal for conjugate pad optimization for particularly sensitive assays. Manufactured to enable optimization giving the same results every time. Pads rewet quickly and naturally without requiring surfactant treatment, facilitating simplified production. Standard 14 has higher absorption capacity and greater flexibility, while Standard 17 has greater tensile strength for easier manufacturing.

Standard Sizes
Reels are available in the following standard sizes:

12mm x 50m
17mm x 50m
22mm x 50m
27mm x 50m

Track etched membranes

> Track etched membranes

Track etched membranes (TEMs) are extremely thin yet highly controlled membranes. Traditionally, TEMs have been used for sample filtration before critical applications such as HPLC.

Broad Applicability Across Applications

The properties that make TEMs ideal for applications like filtration are becoming increasingly important for diagnostic tests.

Cell capture.
Tightly controlled filtration properties allow you to capture cells of a specific pore size on the membrane surface. Enables cells to be detected in a clearer environment, yielding improved accuracy.

Particle capture and latex agglutination.
The distinct pore size of TEMs enables the capture of particles of known sizes. Now you can construct assays in which capture reagents are bound to a latex bead (i.e., bead capture assays) or the antigen causes particle agglutination whereby the agglutinated clusters are captured on the membrane surface.

Biosensors.
With biosensors, it is important to control liquid migration rates onto the sensor and prevent potential contaminants from reaching the sensor surface. The flow properties of a TEM can be chosen to yield the correct flow of liquids or gases through the membrane in order to obtain optimal sensitivity. It is also possible to modify surface properties so that membranes will serve as barriers to contaminants.

Erythrocyte deformability testing.
Since healthy erythrocytes are highly flexible, they will readily change shape to pass through small openings. In several haemopathies, the ability of the cell to flex is reduced to the extent that it can no longer pass through a small aperture. When TEMs are used as a barrier to abnormal erythrocytes, it is possible to test for disease states.

In short, the degree of control that is possible in TEM manufacturing not only gives rise to a number of applications in which standard materials would fail, but also makes process validation and regulatory control easier and more intuitive.

Features and Benefits

• Defined pore size.
  The claimed nominal pore size is the largest pore size present in the membrane. The intra-lot variation in pore size is typically between two and three percent.
• Biologically inert.
  Since TEMs are manufactured from PC, the possibilities of assay interference are remote.
• Control of flow rate.
  TEMs are available with hydrophobic or hydrophilic surfaces in a range of pore sizes and pore densities. The flow rate of liquid through the membrane can therefore be tightly controlled.