BMP-2
Home Up BMP-2 Granulocyte Colony Sti.Factor GM-CSF IL-12 Interferon gamma TNF-α M-CSF M-CSF mouse Osteoclast Differentiation Fact. Osteoprotegerin

 

For USA: 1-800-771-7001

Specification sheet

Recombinant Human BMP-2

Catalog No:PC105-1 2 micrograms 180€
Catalog No:PC105-2 5 micrograms 225€
Catalog No:PC105-3 10 micrograms 275€
Catalog No:PC105-4 25 micrograms 560€
Catalog No:PC105-5 100 micrograms CALL/EMAIL
Catalog No:PC105-6 1 mg CALL/EMAIL
Source E. Coli
Formulation

The sterile filtered solution was lyophilized from 10 mM Sodium Citrate, pH 3.5.

Reconstitution Centrifuge briefly to bring the protein down from the top of the vial. Reconstitute in water containing BSA (50 μg of BSA per 1 μg of protein) to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other buffers and stored at 4 degree Celsius for 1 week or stored at -20 degree Celsius for future use. Avoid repeated freeze-thaw cycles.
Storage The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20 degree Celsius. Reconstituted BMP-2 should be stored in working aliquots at -20 degree Celsius.
Purity greater than 98% by SDS-PAGE.
Biological Activity The ED50 as determined by the cytolysis of MC3T3-E1 cells is less than 50 ng/mL.
Description BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate promote and regulate bone development, growth, remodeling and repair. However, it is now clear that in addition to their role in bone and cartilage morphogenesis, BMPs are also involved in prenatal development and postnatal growth of eye, heart, kidney, skin and other tissues.
In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis. It is also expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary and small intestine. Recombinant human BMP-2 is a 26 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
 
Endotoxin Endotoxin level les than F0.1 ng/μg.
Country of Origin USA