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BAPTA and its derivatives are calcium
chelators that are commonly used to form calcium buffers
with well-defined calcium concentrations. By injecting the
chelators into cells or by incubating cells with the AM
ester form of the chelators, one can control the cytosolic
calcium concentration, an important means to study the roles
of calcium. Key advantages of these calcium chelators
include relative insensitivity toward intracellular pH
change and fast release of calcium. Biotium offers several
BAPTA chelators with calcium dissociation constants covering
the biologically significant range from 10-7 to
10-2 M.
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