Animal ID:
RB1437-1438
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09%
(W/V) sodium azide. This antibody is purified through a
protein G column and eluted out with both high and low pH
buffers and neutralized immediately after elution then
followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long
term storage store at -20ºC. Avoid repeated freeze-thaw
cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 45 -
73 ["LPPPLGGAAGHPGC, CKPVLKEGQV "] of the human dickkopf
(DKK1) protein. |
Accession number:
AAQ89364 |
Description:
WNT proteins influence many aspects of embryonic development,
and their activities are regulated by several secreted
antagonists, including
dickkopf (DKK1). DKK1 may play a key role for the
induction of head structures. |
Alternative Name(s):
dickkopf (Xenopus laevis) homolog 1, SK |
References:
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Gregory CA, Singh H, Perry AS, Prockop DJ: The Wnt
signaling inhibitor dickkopf-1 is required for reentry into
the cell cycle of human adult stem cells from bone marrow.
J. Biol. Chem. 278(30): 28067-28078 (2003).
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Brott BK, Sokol SY: Regulation of Wnt/LRP signaling by
distinct domains of Dickkopf proteins. Mol. Cell. Biol.
22(17): 6100-6110 (2002).
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Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P,
Srivenugopal KS; Human Dkk-1, a gene encoding a Wnt
antagonist, responds to DNA damage and its overexpression
sensitizes brain tumor cells to apoptosis following
alkylation damage of DNA. Oncogene 21(6): 878-889
(2002).
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