Animal ID:
RB0275-0276
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09%
(W/V) sodium azide. This antibody is purified through a protein G
column and eluted out with both high and low pH buffers and
neutralized immediately after elution then followed by dialysis
against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term
storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1 - 15
[MSSGLWSQEKVTSPY] of the human cylindromatosis (CYLD) protein.
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Accession number:
NM_015247 |
Description:
The
cylindromatosis (CYLD) protein is 956 amino acids long and has
been implicated in cylindromatosis (Turban Tumor Syndrome) and may
also play a role in oncogenesis. Germline Mutations in the CYLD
cause cylindromas: benign adnexal skin tumors often found in the
scalp area. In most cases the second wild-type allele is lost in
tumor tissue, suggesting that CYLD functions as tumor suppressor.
It has been demonstrated that inhibition of CYLD enhances
activation of NF-kappaB; inhibition of CYLD also increases
resistance to apoptosis, suggesting a mechanism through which loss
of CYLD contributes to oncogenesis. |
Alternative Name(s):
Turban tumor syndrome protein, cylindromatosis protein, EAC, CDMT,
CYLD1, HSPC057, KIAA0849, Brooke¿Spiegler syndrome protein, BSS,
familial cylindromatosis protein |
References:
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Regamey A, Hohl D, Liu JW, Roger T, Kogerman P, Toftgard R,
Huber M: The tumor suppressor CYLD interacts with TRIP and
regulates negatively nuclear factor kappaB activation by tumor
necrosis factor.J. Exp. Med. 198(12): 1959-1964 (2003).
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Hu G, Onder M, Gill M, Aksakal B, Oztas M, Gurer MA, Celebi JT:
A novel missense mutation in CYLD in a family with
Brooke-Spiegler syndrome.J. Invest. Dermatol. 121(4):
732-734 (2003).
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Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D,
Courtois G: The tumour suppressor CYLD negatively regulates
NF-kappaB signalling by deubiquitination.Nature 424(6950):
801-805 (2003).
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