Anti-Interleukin- Alpha (Il-4R) (CD124).
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Product Details: Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)

Basic Information

 
Product ID: MR-441-7
Product Name: Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)
Unit: 250µg
Price: 465 €
Availability: Available
Category: Growth Factors, Cytokines, Receptors and their Antibodies
Subcategory: Monoclonal Antibodies (Growth Factors/Cytokines/Receptors)

 

Product Details

 
Description: IgG fraction from mouse monoclonal antibody (clone 6B1/E7) obtained by immunization of mice with the extra-cellular domain of interleukin 4 receptor alpha chain (38 kDa). The IgG fraction was purified using Protein G-Sepharose.

 
Isotype: IgG1
Biological Activity: This antibody can be used for ELISA assay (1:2,000 dilution). The IL-4R alpha chain binds both IL-4 and IL-13 and activates many common signal transduction pathways. The extra-cellular domain, also called CD124, inhibits IL-4-mediated cell proliferation and IL-5 up-regulation by T-cells. The IL-4/IL-13 responses are involved in the regulation of the differentiation of CD4+ T cells and class switching to IgG1 and IgE.

 
Formulation: Solution at 0.95 mg/mL in PBS
Storage Conditions: Store at -20oC
Stability: Stable for at least one year. Avoid repeated freezing and thawing.
Temperature: -20°C
References: Nelms, K. et. al. (1999) Annu. Rev. Immunol. 17, 701 - 738