DESCRIPTION
Creatinine is synthesized in the body at a fairly constant rate from
creatine, which is produced during muscle contractions from creatine
phosphate. In the blood, creatinine is removed by filtration through the
glomeruli of the kidney and is secreted into urine. In healthy individuals,
creatinine secretion is independent of diet and is fairly constant, the
creatinine clearance test has become one of the most sensitive tests for
measuring glomerular filtration rate. In kidney disease, creatinine levels
in the blood are elevated, whereas the creatinine clearance rate and hence
the urine levels are diminished. Creatinine test is most widely used to
assess kidney function.
Simple, direct and automation-ready procedures for measuring creatinine
concentration in biological samples are very popular in clinical studies.
BioAssay Systems' creatinine assay kit is designed to measure creatinine
directly in biological samples without any pretreatment. The improved Jaffe
method utilizes picrate that forms a red colored complex with creatinine.
The intensity of the color, measured at 510nm, is directly proportional to
the creatinine concentration in the sample. The optimized formulation
substantially reduces interference by substances in the raw samples.
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