Animal ID:
RB1437-1438
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09%
(W/V) sodium azide. This antibody is purified through a protein G
column and eluted out with both high and low pH buffers and
neutralized immediately after elution then followed by dialysis
against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term
storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 45 - 73
["LPPPLGGAAGHPGC, CKPVLKEGQV "] of the human dickkopf (DKK1)
protein. |
Accession number:
AAQ89364 |
Description:
WNT proteins influence many aspects of embryonic development, and
their activities are regulated by several secreted antagonists,
including
dickkopf (DKK1). DKK1 may play a key role for the induction of
head structures. |
Alternative Name(s):
dickkopf (Xenopus laevis) homolog 1, SK |
References:
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Gregory CA, Singh H, Perry AS, Prockop DJ: The Wnt signaling
inhibitor dickkopf-1 is required for reentry into the cell cycle
of human adult stem cells from bone marrow. J. Biol. Chem.
278(30): 28067-28078 (2003).
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Brott BK, Sokol SY: Regulation of Wnt/LRP signaling by
distinct domains of Dickkopf proteins. Mol. Cell. Biol.
22(17): 6100-6110 (2002).
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Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal
KS; Human Dkk-1, a gene encoding a Wnt antagonist, responds
to DNA damage and its overexpression sensitizes brain tumor
cells to apoptosis following alkylation damage of DNA.
Oncogene 21(6): 878-889 (2002).
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For Research Use Only. Not for Diagnostic
or Therapeutic Use.
Purchase does not include or carry any right to resell or
transfer this product either as a stand-alone product or as a
component of another product. Any use of this product other than
the permitted use without the express written authorization of
Orbigen, Inc. is strictly prohibited |
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